Biochemical aspects of cesium administration in tumor-bearing mice.

Abstract

The effect of pretreatment with CsCl on mice bearing sarcoma I implants was studied as a function of duration of treatment period, life span and tissue Cs+ and K+ levels. Treatment with CsCl for 14 consecutive days prior to sarcoma implantation resulted in initial reduction of the tumor-mediated mortality compared to controls and to a one week pretreatment period with identical doses of CsCl. A large accumulation of endogenous K+ was noted in tumor mass compared to nonmalignant tissue of the same animals or to tumor-free controls receiving identical Cs-treatment. The entry of exogenously administered Cs+ into malignant tissue was less than that accumulating in respective controls. The accumulation of Cs+ in tumor mass was dose-dependent. The ratio of K+:C+ was greater in tumor tissue than in nonmalignant tissue. The results suggest that a critical balance between these alkali metals may be required for adequate Cs effect against the tumor studied.

• Authors: F S Messiha
• Journal: Pharmacology, biochemistry, and behavior (Pharmacol Biochem Behav) Vol. 21 Suppl 1 Pg. 27-30 ( 1984) ISSN: 0091-3057 [Print] United States
• PMID: 6522430 (Publication Type: Journal Article)

Chemical References

• Chlorides
• Cesium
• cesium chloride
• Potassium

Topics

• Animals
• Cesium (metabolism, therapeutic use)
• Chlorides
• Male
• Mice
• Mice, Inbred A
• Potassium (metabolism)
• Sarcoma, Experimental (drug therapy, metabolism)