Abstract |
To study the hemodynamic and metabolic effects of isoptin, the drug was infused intravenously to 15 patients with acute transmural myocardial infarction at a dosage of 0.13-0.17 mg per kg bw. Along with the parameters of the central hemodynamics and the myocardial contractility of the left ventricle, using extraction coefficients the authors determined some parameters of myocardial metabolism. The drug was well tolerated by the patients, virtually did not affect the parameters of myocardial contractility, decreased the work of the heart at the expense of a significant reduction of the after-load and lowered manifestations of the ischemia of the intact myocardium (the coefficient of lactate extraction by the myocardium was found to elevate).
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Authors | V D Vakhliaev, E V Pomerantsev, I V Serova, I V Bogatyrev, M G Poltavskaia |
Journal | Kardiologiia
(Kardiologiia)
Vol. 24
Issue 10
Pg. 60-3
(Oct 1984)
ISSN: 0022-9040 [Print] Russia (Federation) |
Vernacular Title | Primenenie izoptina v ostrom periode infarkta miokarda (vliianie na gemodinamiku i metabolizm miokarda). |
PMID | 6521184
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Fatty Acids, Nonesterified
- Lactates
- Verapamil
- Glucose
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Topics |
- Adult
- Fatty Acids, Nonesterified
(metabolism)
- Glucose
(metabolism)
- Hemodynamics
(drug effects)
- Humans
- Lactates
(metabolism)
- Male
- Middle Aged
- Myocardial Infarction
(drug therapy, physiopathology)
- Myocardium
(metabolism)
- Verapamil
(therapeutic use)
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