Single cell origin of radiation-induced thymic lymphoma in mice with cellular mosaicism.

Abstract

The clonal origin of radiation-induced thymic lymphoma was studied in mice with cellular mosaicism for phosphoglycerate kinase (PGK). Repeated whole-body X-irradiations (4 doses, 1.7 Gy each) with intervals of 7 days resulted in development of thymic lymphomas in the mosaic mice. PGK from all lymphomas gave only a single spot on electrophoresis. The results demonstrate the single cell origin of the thymic lymphoma.

• Authors: M Bessho, I Jinnai, K Hirashima, K Tanaka, H Tanooka
• Journal: Gan (Gan) Vol. 75 Issue 11 Pg. 1002-5 (Nov 1984) ISSN: 0016-450X [Print] Japan
• PMID: 6519394 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Phosphoglycerate Kinase

Topics

• Animals
• Female
• Lymphoma (enzymology, etiology, pathology)
• Male
• Mice
• Mice, Inbred C3H
• Mosaicism
• Neoplasms, Radiation-Induced (pathology)
• Neoplastic Stem Cells
• Phosphoglycerate Kinase (analysis)
• Thymus Neoplasms (enzymology, etiology, pathology)