Human tumor cell membrane glycoprotein associated with protein kinase activity.

Abstract	A mouse MAb3 50H.19 raised against the human melanoma cell line MEL-T binds to carcinoma cell lines, carcinoma biopsy material, and certain epithelia of normal tissues. It immunoprecipitates two components from carcinoma cell lines, a major component of 22 kd which is O-glycosylated and a minor one of 24 kd which is additionally N-glycosylated. The immunocomplexed 50H.19 antigen exhibits protein kinase activity with substrate-specificity for casein and phosvitin, but not for histones. It phosphorylates on serine and threonine, but not tyrosine residues. Enzyme activity is cyclic AMP-independent.
Authors	J Seehafer, B M Longenecker, A R Shaw
Journal	International journal of cancer (Int J Cancer) Vol. 34 Issue 6 Pg. 815-9 (Dec 15 1984) ISSN: 0020-7136 [Print] United States
PMID	6511125 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Antibodies, Monoclonal Antigens, Neoplasm Glycoproteins Membrane Proteins Protein Kinases
Topics	Antibodies, Monoclonal (immunology) Antigens, Neoplasm (analysis) Cell Membrane (enzymology) Glycoproteins (analysis) Humans Membrane Proteins (analysis) Neoplasms (enzymology) Phosphorylation Protein Kinases (analysis)

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