Abstract |
Erythrocyte concentrates are preferred increasingly to whole- blood transfusions in treatment of neonatal anemias. By means of their application even very important restorations of hematocrit are possible without the risk of fluid overload. A possible side-effect of these erythrocyte suspensions is a transfusion mediated acidosis, which depends on the used buffer solution, temperature and storage conditions before and during use. The case report of a preterm infant with Rh-Erythroblastosis and postpartal shock demonstrates the problem of an additional acidosis caused by the ACD-adenin stabilised erythrocyte concentrate. The impression of a transfusion mediated acidaemia is confirmed by 30 comparative pH-measurements in ACD-adenin and heparin stored erythrocytes. We conclude that erythrocyte transfusions in very ill neonates with severe disturbances of metabolism and reduced organ functions should be done with heparin erythrocyte preparations.
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Authors | M Abel, H O Fürste, W Pringsheim, J W Sievers, J Otto |
Journal | Infusionstherapie und klinische Ernahrung
(Infusionsther Klin Ernahr)
Vol. 11
Issue 5
Pg. 267-9
(Oct 1984)
ISSN: 0378-0791 [Print] Switzerland |
Vernacular Title | Transfusionsbedingte Säurebelastung durch Erythrozytenkonzentrate im Neugeborenenalter. |
PMID | 6511085
(Publication Type: Case Reports, English Abstract, Journal Article)
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Chemical References |
- acid citrate dextrose
- Citric Acid
- Glucose
|
Topics |
- Acid-Base Equilibrium
(drug effects)
- Acidosis
(etiology)
- Adult
- Blood Transfusion, Intrauterine
(adverse effects)
- Citric Acid
- Erythroblastosis, Fetal
(therapy)
- Erythrocyte Transfusion
- Exchange Transfusion, Whole Blood
(adverse effects)
- Female
- Glucose
(adverse effects, analogs & derivatives)
- Humans
- Infant, Newborn
- Pregnancy
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