Abstract |
Effects of carminomycin on the colony-forming ability of bone marrow haemopoietic stem cells (CFUs) were compared in normal mice with steady state and actively regenerating bone marrow, and in P-388 and La leukemia-bearing mice. CFUs assays were performed 24 h after treatment of donor mice with the increasing doses of the drug. Leukemia-bearing mice received carminomycin on the 5th day after transplantation. The dose-effect curves were exponential for CFUS normal mice with both the steady state and active proliferation state of bone marrow. The maximal effect was found 24 h after injection of 0.7 mg/kg of carminomycin (ED50 for CFUS) being more pronounced in regenerating bone marrow. The dose-effect curves for leukemias were also exponential. In the case of La leukemia the killing of CFUs by carminomycin was the highest as compared with P-388 leukemia.
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Authors | G I Kozinets, L E Ivanova, O K Khanykova, T V Kuznetsova, N A Rudneva |
Journal | Eksperimental'naia onkologiia
(Eksp Onkol)
Vol. 6
Issue 5
Pg. 59-62
( 1984)
ISSN: 0204-3564 [Print] Ukraine |
Vernacular Title | Kolonieobrazuiushchaia sposobnost' gemopoéticheskikh kletok kostnogo mozga mysheĭ s perevivnym leĭkozom pri vvedenii karminomitsina. |
PMID | 6510345
(Publication Type: English Abstract, Journal Article)
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Chemical References |
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Topics |
- Animals
- Carubicin
(therapeutic use, toxicity)
- Colony-Forming Units Assay
- Daunorubicin
(analogs & derivatives)
- Female
- Hematopoietic Stem Cells
(drug effects, pathology)
- Leukemia P388
(drug therapy, pathology)
- Leukemia, Experimental
(drug therapy, pathology)
- Mice
- Mice, Inbred CBA
- Neoplasm Transplantation
- Rats
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