[Antineoplastic and toxic effects of blastolysin in the treatment of spontaneous mammary cancer in dogs].

Abstract

The anticancer activity and toxicity of blastolysin were studied in 13 dogs with mammary cancer using two different schedules. The agent was given 5 times in a dose of 2.5-10 mg/kg with a 72 h interval (the first schedule) and 10 times in a dose of 0.4-1.7 mg/kg in 24 h (the second schedule). The first schedule exhibited the highest anticancer effect with the least toxicity. Blastolysin was found to depress erythropoiesis.

• Authors: S V Zontov, Iu I Rampan, A B Syrkin, A V Iliukhin, N V Kliuchanskaia
• Journal: Eksperimental'naia onkologiia (Eksp Onkol) Vol. 6 Issue 2 Pg. 58-60 ( 1984) ISSN: 0204-3564 [Print] Ukraine
• Vernacular Title: Protivoopukholevoe i toksicheskoe deĭstvie blastolizina pri terapii spontannogo raka molochnykh zhelez u sobak.
• PMID: 6510337 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anti-Bacterial Agents
• Antibiotics, Antineoplastic
• Glycopeptides
• blastolysin

Topics

• Animals
• Anti-Bacterial Agents
• Antibiotics, Antineoplastic (administration & dosage, therapeutic use, toxicity)
• Dogs
• Erythropoiesis (drug effects)
• Female
• Glycopeptides (administration & dosage, therapeutic use, toxicity)
• Mammary Neoplasms, Experimental (drug therapy)