Inhibition of carrageenan edema formation by organotin compounds.

Abstract

The effects of a single p.o. dose of 0.3-10 mg/kg of organotin compounds such as dibutyltin dichloride (Bu2SnCl2) and triphenyltin chloride (Ph3SnCl) on the development of edema after subplantar injection of 0.5 mg of carrageenan in 0.05 ml of pyrogen-free saline were examined as compared with those of hydrocortisone. Bu2SnCl2, Ph3SnCl and hydrocortisone did not significantly inhibit the development of the first phase of edema at any dose level, but produced more than 90, 70 and 90% inhibition of the second phase, respectively, at a dose of 10 mg/kg 1 hr before the irritant. Moreover, these inhibitions of the second phase were dose-dependent.

• Authors: Y Arakawa, O Wada
• Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 125 Issue 1 Pg. 59-63 (Nov 30 1984) ISSN: 0006-291X [Print] United States
• PMID: 6508808 (Publication Type: Journal Article)

Chemical References

• Organotin Compounds
• Carrageenan
• triphenyltin chloride
• dibutyldichlorotin
• Hydrocortisone

Topics

• Animals
• Carrageenan
• Edema (chemically induced, prevention & control)
• Hydrocortisone (pharmacology)
• Male
• Organotin Compounds (pharmacology)
• Rats
• Rats, Inbred Strains