Involvement of chromosome No. 2 in chromosome changes in primary leukemia induced in rats by N-nitroso-N-butylurea.

Abstract

Cytogenetic studies were done on 34 primary leukemias induced by N-nitroso-N-butylurea (NBU) in outbred Long-Evans rats. The results revealed leukemia cells with No. 2 trisomy and long No. 2 chromosome, which characterized the leukemias induced by polycyclic hydrocarbon carcinogens such as 7,12-dimethylbenz[a]anthracene and 7,8,12-trimethylbenz[a]-anthracene. These findings suggest a common mode of action of different carcinogenic chemicals at the chromosome level, although the lower incidence of these chromosome changes and of erythroblastic leukemias with NBU suggests subtle difference in their actions.

• Authors: H Uenaka, N Ueda, S Maeda, T Sugiyama
• Journal: Journal of the National Cancer Institute (J Natl Cancer Inst) Vol. 60 Issue 6 Pg. 1399-404 (Jun 1978) ISSN: 0027-8874 [Print] United States
• PMID: 650703 (Publication Type: Journal Article)

Chemical References

• Nitrosourea Compounds

Topics

• Animals
• Chromosome Aberrations
• Female
• Karyotyping
• Leukemia, Experimental (chemically induced, genetics, pathology)
• Male
• Nitrosourea Compounds
• Rats
• Trisomy