[Thiamine triphosphate content of the liver of albino rats with different levels of thiamine].

Abstract

Content of thiamine triphosphate (TTP) was studied in rat liver tissue under conditions of normal state, thiamine deficiency and after loading with thiamine. The concentration of TTP in hepatocytes of control animals was found to be 3.2-3.6 micrograms/g, corresponding to 40% of the total thiamine pool in the cells. The TTP appears to serve as a reserve of vitamin B1 deposited in mitochondria of the cells in which the biosynthesis of thiamine pyrophosphate of their own did not take place. Administration of thiamine did not induce the TTP overproduction in hepatocytes; the content of TTP was maintained in the mitochondria of the hepatocytes at the constant level.

• Authors: A I Voskoboev, E A Gritsenko, Iu M Ostrovskiĭ
• Journal: Voprosy meditsinskoi khimii (Vopr Med Khim) 1984 Jul-Aug Vol. 30 Issue 4 Pg. 106-10 ISSN: 0042-8809 [Print] Russia (Federation)
• Vernacular Title: Soderzhanie tiamintrifosfata v pecheni belykh krys pri pazlichnoĭ obespechennosti tiaminom.
• PMID: 6506575 (Publication Type: English Abstract, Journal Article)

Chemical References

• Thiamine Triphosphate
• Thiamine

Topics

• Animals
• Chromatography, Ion Exchange
• Female
• Liver (metabolism)
• Mitochondria, Liver (metabolism)
• Rats
• Thiamine (administration & dosage, analogs & derivatives, metabolism)
• Thiamine Deficiency (metabolism)
• Thiamine Triphosphate (biosynthesis)