Plasma oncomodulin is proportional to tumour burden in rats bearing Morris hepatomas 5123D, 5123tc, 7288 and 7777.

Abstract

The small acidic calcium-binding protein, oncomodulin, was detected by radioimmunoassay in the plasma of rats bearing Morris hepatomas 5123D, 5123tc, 7288ctc, and 7777. The concentration of plasma oncomodulin was proportional to the tumour burden. When the tumour was surgically removed, the plasma oncomodulin level dropped to undetectable levels. No oncomodulin was detected in the circulation of normal rats.

• Authors: J P MacManus
• Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (Tumour Biol) Vol. 5 Issue 3-4 Pg. 189-97 ( 1984) ISSN: 1010-4283 [Print] Netherlands
• PMID: 6505549 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Calcium-Binding Proteins
• Neoplasm Proteins
• oncomodulin

Topics

• Animals
• Calcium-Binding Proteins (blood)
• Chromatography, High Pressure Liquid
• Liver Neoplasms, Experimental (blood)
• Neoplasm Proteins (blood)
• Radioimmunoassay
• Rats