Influence of DL-2-phenyl[6-ethoxybenzothiazolyl-(2)-thio]propionic acid (EMD 34853) on gallstone formation in hamsters.

Abstract	The effects of two levels (50 and 167 mg/kg) of a new hypocholesterolemic drug (EMD 34853) on gallstone formation in hamsters were investigated. Lithogenicity was inhibited by 28-45%. Levels of biliary lipids (cholesterol, phospholipid, bile acids) were reduced in the drug-treated animals.
Authors	D Kritchevsky, D M Klurfeld
Journal	Pharmacological research communications (Pharmacol Res Commun) Vol. 16 Issue 2 Pg. 111-5 (Feb 1984) ISSN: 0031-6989 [Print] United States
PMID	6504964 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References	Anticholesteremic Agents Bile Acids and Salts Thiazoles tazasubrate Cholesterol
Topics	Animals Anticholesteremic Agents (pharmacology) Bile (drug effects, metabolism) Bile Acids and Salts (metabolism) Cholelithiasis (prevention & control) Cholesterol (metabolism) Cricetinae Dose-Response Relationship, Drug Lipid Metabolism Male Mesocricetus Thiazoles (pharmacology)

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