Empedopeptin (BMY-28117), a new depsipeptide antibiotic. I. Production, isolation and properties.

Abstract	Empedopeptin is a new antibiotic produced by empedobacter haloabium nov. sp. (ATCC 31962). It is a water-soluble depsipeptide antibiotic containing eight amino acid residues and a C14-fatty acid moiety in the molecule. Although structurally unrelated, empedopeptin and vancomycin have similar antimicrobial spectra against aerobic and anaerobic Gram-positive bacteria including antibiotic-resistant strains. Empedopeptin is highly active in vivo in mice against systemic infections of Staphylococcus aureus, Streptococcus pyogenes and Clostridium perfringens. Empedopeptin is not absorbed orally.
Authors	M Konishi, K Sugawara, M Hanada, K Tomita, K Tomatsu, T Miyaki, H Kawaguchi, R E Buck, C More, V Z Rossomano
Journal	The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 37 Issue 9 Pg. 949-57 (Sep 1984) ISSN: 0021-8820 [Print] England
PMID	6501108 (Publication Type: Journal Article)
Chemical References	Anti-Bacterial Agents Oligopeptides empedopeptin
Topics	Animals Anti-Bacterial Agents (biosynthesis, isolation & purification, pharmacology) Chemical Phenomena Chemistry Flavobacterium (classification, metabolism) Mice Microbial Sensitivity Tests Oligopeptides (isolation & purification, pharmacology)

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