Enhancement of mouse immune system by pyrrolomycin B.

Abstract	Pyrrolomycin B enhanced both humoral immune response and delayed-hypersensitivity against sheep red blood cells in mice. In spleen cell culture it was a weak inhibitor of mitogenesis. However, in combination with concanavalin A, there was stimulation of mitogenesis in spleen cell culture. Pyrrolomycin B also enhanced phagocytosis of yeasts by peritoneal macrophages after in vivo administration to mice. Thus, pyrrolomycin B, formerly isolated as an antibiotic agent, is an immunopotentiator possibly acting on the membrane of lymphocytes or macrophages.
Authors	K Umezawa, M Ishizuka, T Sawa, T Takeuchie
Journal	The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 37 Issue 10 Pg. 1253-6 (Oct 1984) ISSN: 0021-8820 [Print] England
PMID	6501096 (Publication Type: Journal Article)
Chemical References	Adjuvants, Immunologic Anti-Bacterial Agents Pyrroles pyrrolomycin B
Topics	Adjuvants, Immunologic Animals Anti-Bacterial Agents (pharmacology) Female Immunity (drug effects) Mice Mice, Inbred Strains Mitosis (drug effects) Phagocytosis (drug effects) Pyrroles (pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!