[The effect of preparations of microbial glutamin(asparagin)ase on cultured tumor cells].

Abstract

Glutamin (asparagin)ase from Pseudomonas boreopolis 526 is shown to produce a cytotoxic effect on the human ovary carcinoma cells (CaOv line), Fisher lympholeukemia (L-8 line) and Burkitt's lymphoma cells (P3HR line). A significant inhibition of the DNA synthesis is found in L-8 and P3HR cell lines. The enzyme is less active in the cells of the CaOv line.

• Authors: A A Pekhov, O S Zhukova, V A Zanin, V A Dobrynin, T T Berezov
• Journal: Eksperimental'naia onkologiia (Eksp Onkol) Vol. 6 Issue 1 Pg. 55-7 ( 1984) ISSN: 0204-3564 [Print] Ukraine
• Vernacular Title: Deĭstvie preparatov glutamin[asparagin]azy iz mikroorganizmov na opukholevye kletki v kul'ture.
• PMID: 6499733 (Publication Type: English Abstract, Journal Article)

Chemical References

• DNA, Neoplasm
• Amidohydrolases
• glutamin-(asparagin-)ase

Topics

• Amidohydrolases (pharmacology)
• Burkitt Lymphoma (metabolism)
• Cells, Cultured
• DNA, Neoplasm (biosynthesis)
• Female
• Humans
• Neoplasms (metabolism)
• Ovarian Neoplasms (metabolism)
• Pseudomonas (enzymology)