N-acetylpenicillamine potentiated excretion of methyl mercury in rat bile: influence of S-methylcysteine.
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| Abstract |
N-acetylpenicillamine, 5 mmol/kg body weight increased biliary excretion of methyl mercury more than three fold. Upon simultaneous administration of the same dose of N-acetylpenicillamine and 2,5 mmol/kg body weight of S-methylcysteine biliary excretion of methyl mercury increased only 1.5 fold. In both cases biliary sulfhydryl concentration increased to the same extent, about 5 fold. Decreased biliary excretion of methyl mercury, as a result of liver depletion of reduced glutathione by cyclohexene oxide, could be restored by N-acetylpenicillamine. This restoration could be depressed by S-methylcysteine. The experiments undertaken indicate that N-acetylpenicillamine potentiated methyl mercury excretion occurs by a glutathione S-transferase dependent mechanism. Bile, collected after successive administration of methyl mercuric chloride, cyclohexene oxide, S-methylcysteine and N-acetylpenicillamine contained the methyl mercuric derivatives of N-acetylpenicillamine and glutathione together with other methyl mercury carrying components not present in control bile. Whether these components play any role in the mechanism of N-acetylpenicillamine potentiated methyl mercury excretion cannot be stated from the present investigation.
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| Authors | T Refsvik |
| Journal | Acta pharmacologica et toxicologica (Acta Pharmacol Toxicol (Copenh)) Vol. 55 Issue 2 Pg. 121-5 (Aug 1984) ISSN: 0001-6683 [Print] Denmark |
| PMID | 6496113 (Publication Type: Journal Article) |
| Chemical References |
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