[Kidney function and mitochondrial metabolism in excluded renal blood flow against a background of diuretic action].

Abstract

Single administration of furosemid, etacrine acid and mannitol prior to switching off circulation in the only kidney for 2.5 hrs preserves the renal tissue from ischemic lesion, aids to normalizing the excretory processes on the 2nd--4th days of postischemic period, reduces duration of the oligo--anuric phase in acute renal insufficiency, and raises survival rate in the rats. The above substances are ineffective if administered after cessation of the ischemic period. Etacrin acid and novurit suppress functional activity of isolated mitochondria incubated in hypoxia at 37 degrees. Furosemid and mannitol in these conditions exert no effect. Preliminary administration of furosemid aids to preservation of lumen in proximal tubules of superficial nephrones both during cessation of the renal circulation and in the postischemic period.

• Authors: A A Lebedev, A V Dubishchev
• Journal: Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova (Fiziol Zh SSSR Im I M Sechenova) Vol. 64 Issue 3 Pg. 342-8 (Mar 1978) ISSN: 0015-329X [Print] Russia (Federation)
• Vernacular Title: Funktsiia pochek i metabolizm mitochondriĭ pri vykliuchenii pochechnogo krovotoka na fone deĭstviia diuretikov.
• PMID: 648664 (Publication Type: English Abstract, Journal Article)

Chemical References

• Diuretics
• Drug Combinations
• Organomercury Compounds
• Mannitol
• Unithiol
• Furosemide
• Theophylline
• Ethacrynic Acid

Topics

• Animals
• Diuretics (pharmacology)
• Drug Combinations
• Ethacrynic Acid (pharmacology)
• Female
• Furosemide (pharmacology)
• Ischemia (physiopathology)
• Kidney (blood supply, drug effects, physiology)
• Kidney Tubules, Proximal (drug effects)
• Male
• Mannitol (pharmacology)
• Mitochondria (drug effects, metabolism)
• Organomercury Compounds (pharmacology)
• Rats
• Theophylline (pharmacology)
• Unithiol (pharmacology)