Abstract |
Pretazettine hydrochloride (PTZ) has been found to inhibit protein synthesis, without being inhibitory to DNA and RNA, in Rauscher leukemic blood cells in mice for at least 6 h after its administration. With comparison to Virazole and cycloheximide, the specific anti-Rauscher virus activity of PTZ has been demonstrated only in acutely-infected NIH/3T3 cells but not in chronically-infected cells. It is not certain that the inhibitory action of PTZ on reverse transcriptase is contributory to its therapeutic activity in leukemic mice.
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Authors | E Furusawa, S Furusawa, J Y Lee, S Patanavanich |
Journal | Chemotherapy
(Chemotherapy)
Vol. 24
Issue 4
Pg. 259-66
( 1978)
ISSN: 0009-3157 [Print] Switzerland |
PMID | 648237
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Alkaloids
- Antineoplastic Agents
- DNA, Neoplasm
- Macromolecular Substances
- Neoplasm Proteins
- RNA, Neoplasm
- DNA-Directed DNA Polymerase
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Topics |
- Alkaloids
(therapeutic use)
- Animals
- Antineoplastic Agents
(therapeutic use)
- Cell Line
- Cytotoxicity Tests, Immunologic
- DNA, Neoplasm
(biosynthesis)
- DNA-Directed DNA Polymerase
(metabolism)
- Drug Evaluation, Preclinical
- Leukemia, Experimental
(drug therapy)
- Macromolecular Substances
- Mice
- Neoplasm Proteins
(biosynthesis)
- RNA, Neoplasm
(biosynthesis)
- Rauscher Virus
(drug effects)
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