Abstract |
Four hematopoietic in vitro cell lines (Hodgkin derived cell lines L428 and L540, Burkitt's lymphoma line BJAB and the lymphoblastic lymphoma line of T-cell type L735) were transplanted into nude mice (NMRI nu/nu) intramuscularly and intracerebrally as well. Tumor bearing mice were treated with intraperitoneal administration of Cyclophosphamide, Adriamycin, Etoposid and Vindesine. Therapy results in both systems were proven by Student's t-test and significances were compared. Resistance and sensitivity of cell lines tested in the i.c.-system were largely in accordance with the i.m.-system. Best results of treatment were achieved with the T- lymphoma line L735 treated with Cyclophosphamide and Etoposid. Cyclophosphamide induced complete remission of i.m. tumors in several cases whereas in the nude mouse brain the L735 cell relapsed and showed a more aggressive growth and diminished drug sensitivity.
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Authors | H H Kirchner, A Engert, V Diehl |
Journal | Behring Institute Mitteilungen
(Behring Inst Mitt)
Issue 74
Pg. 329-36
(May 1984)
ISSN: 0301-0457 [Print] Germany |
PMID | 6477360
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Animals
- Antineoplastic Agents
(therapeutic use)
- Brain Neoplasms
(drug therapy)
- Cell Line
- Cell Transformation, Neoplastic
(drug therapy)
- Drug Resistance
- Hodgkin Disease
(drug therapy)
- Humans
- Lymphoma
(drug therapy)
- Male
- Mice
- Mice, Nude
- Muscular Diseases
(drug therapy)
- Neoplasm Transplantation
- Neoplasms, Experimental
(drug therapy)
- Transplantation, Heterologous
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