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Experimental chemotherapy of heterotransplanted Hodgkin- and non-Hodgkin-lymphoma cell lines in nude mice.

Abstract
Four hematopoietic in vitro cell lines (Hodgkin derived cell lines L428 and L540, Burkitt's lymphoma line BJAB and the lymphoblastic lymphoma line of T-cell type L735) were transplanted into nude mice (NMRI nu/nu) intramuscularly and intracerebrally as well. Tumor bearing mice were treated with intraperitoneal administration of Cyclophosphamide, Adriamycin, Etoposid and Vindesine. Therapy results in both systems were proven by Student's t-test and significances were compared. Resistance and sensitivity of cell lines tested in the i.c.-system were largely in accordance with the i.m.-system. Best results of treatment were achieved with the T-lymphoma line L735 treated with Cyclophosphamide and Etoposid. Cyclophosphamide induced complete remission of i.m. tumors in several cases whereas in the nude mouse brain the L735 cell relapsed and showed a more aggressive growth and diminished drug sensitivity.
AuthorsH H Kirchner, A Engert, V Diehl
JournalBehring Institute Mitteilungen (Behring Inst Mitt) Issue 74 Pg. 329-36 (May 1984) ISSN: 0301-0457 [Print] Germany
PMID6477360 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents
Topics
  • Animals
  • Antineoplastic Agents (therapeutic use)
  • Brain Neoplasms (drug therapy)
  • Cell Line
  • Cell Transformation, Neoplastic (drug therapy)
  • Drug Resistance
  • Hodgkin Disease (drug therapy)
  • Humans
  • Lymphoma (drug therapy)
  • Male
  • Mice
  • Mice, Nude
  • Muscular Diseases (drug therapy)
  • Neoplasm Transplantation
  • Neoplasms, Experimental (drug therapy)
  • Transplantation, Heterologous

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