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[Phase II study of etoposide (NK 171) in advanced hematological malignancies].

Abstract
A clinical study of a new semisynthetic podophyllotoxin etoposide (NK 171) was performed in patients with various hematological malignancies refractory to standard chemotherapies. The drug was given intravenously in a dose of 100-130 mg/m2/day for five days or orally in a dose of 130-170 mg/m2/day for five days. Out of 9 patients with non-Hodgkin's lymphoma, 2 CR and 4 PR were obtained; out of 4 acute nonlymphoblastic leukemias, 1 CR, and out of 4 chronic myerogenous leukemias 2 CR and 1 PR, were obtained. The dose limiting factor was leukopenia, and alopecia was frequent while other hematologic and gastrointestinal toxicities were mild. Etoposide (NK 171) had no clinical cross resistance to other antitumor agents, thus warranting further clinical trials, in combination chemotherapy against NHL, ANLL and CML-BC.
AuthorsT Yoshida, J Nakanishi, K Ito, S Kobayashi, S Ohtake, S Nakamura, K Hattori
JournalGan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 11 Issue 8 Pg. 1579-84 (Aug 1984) ISSN: 0385-0684 [Print] Japan
PMID6476835 (Publication Type: Clinical Trial, Controlled Clinical Trial, English Abstract, Journal Article)
Chemical References
  • Vincristine
  • Etoposide
  • Doxorubicin
  • Cyclophosphamide
  • Prednisolone
  • Podophyllotoxin
Topics
  • Administration, Oral
  • Adolescent
  • Adult
  • Aged
  • Alopecia (chemically induced)
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Cyclophosphamide (administration & dosage)
  • Doxorubicin (administration & dosage)
  • Drug Administration Schedule
  • Drug Evaluation
  • Etoposide (administration & dosage, adverse effects, therapeutic use)
  • Female
  • Humans
  • Infusions, Parenteral
  • Leukemia (drug therapy)
  • Leukopenia (chemically induced)
  • Lymphoma (drug therapy)
  • Male
  • Middle Aged
  • Nausea (chemically induced)
  • Podophyllotoxin (analogs & derivatives)
  • Prednisolone (administration & dosage)
  • Thrombocytosis (chemically induced)
  • Vincristine (administration & dosage)

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