[Influence of prodigiozan, methyluracil and levamisole on the anti-inflammatory effect of nonsteroid antiphlogistics].

Abstract

The efficacy of the combined use of immunostimulants and anti-inflammatory agents, such as acetylsalicylic acid, voltaren, indomethacin and naproxen was studied in carragenin-induced experimental inflammation. Noninbred albino mice of both sexes were used in the experiments. It was shown that prodigiosan as a therapeutic agent had a pronounced anti-inflammatory action. It potentiated the effect of voltaren used in a dose lower than the ED50 and did not change the anti-inflammatory activity of naproxen, indomethacin and acetylsalicylic acid used in the doses equal to the ED50. The potentiating effect of prodigiosan on voltaren was statistically significant Methyluracil used as a prophylactic agent had an anti-inflammatory effect. Levamisole used as a prophylactic agent or a therapeutic agent did not decrease the edema level. The anti-inflammatory effect of naproxen, indomethacin, acetylsalicylic acid and voltaren did not change, when the drugs were administered to the animals treated with methyluracil and levamisole.

• Authors: A Sh Bogdanova
• Journal: Antibiotiki (Antibiotiki) Vol. 29 Issue 6 Pg. 453-6 (Jun 1984) ISSN: 0003-5637 [Print] Russia (Federation)
• Vernacular Title: Vliianie prodigiozana, metiluratsila i levamizola na protivovospalitel'nyĭ éffekt nesteroidnykh antiflogistikov.
• PMID: 6476809 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Adjuvants, Immunologic
• Anti-Inflammatory Agents
• Polysaccharides, Bacterial
• Levamisole
• Uracil
• 6-methyluracil
• Cyclophosphamide
• Carrageenan
• Prodigiozan

Topics

• Adjuvants, Immunologic (therapeutic use)
• Animals
• Anti-Inflammatory Agents (therapeutic use)
• Carrageenan (pharmacology)
• Cyclophosphamide (pharmacology)
• Drug Evaluation, Preclinical
• Drug Interactions
• Drug Therapy, Combination
• Female
• Immune Tolerance (drug effects)
• Inflammation (chemically induced, drug therapy)
• Levamisole (therapeutic use)
• Male
• Mice
• Polysaccharides, Bacterial (therapeutic use)
• Prodigiozan (therapeutic use)
• Uracil (analogs & derivatives, therapeutic use)