Pinoline, a beta-carboline derivative in the serum and cerebrospinal fluid of patients with schizophrenia.

Abstract

Baseline levels of pinoline, 6-methoxy-1,2,3,4-tetrahydro-beta-carboline (6-MeOTHBC) in the serum and cerebrospinal fluid (CSF) were determined with GLC-mass spectrometry in 13 unmedicated schizophrenic patients and 18 non-psychiatric controls. A detectable concentration of 6-MeOTHBC was always present, but no differences were found between the schizophrenic and the control groups. The serum and the CSF levels of 6-MeOTHBC were not significantly related to such variables as sex, age, subtype of schizophrenia, the quality and/or intensity of the psychopathological symptoms, or the duration of illness. The role of the indoleamines in the aetiopathogenesis of schizophrenia is discussed.

• Authors: R Rimón, M M Airaksinen, I Kari, J Gynther, E Venäläinen, L Heikkilä, J Ryyppö, J Palo
• Journal: Annals of clinical research (Ann Clin Res) Vol. 16 Issue 3 Pg. 171-5 ( 1984) ISSN: 0003-4762 [Print] Finland
• PMID: 6476781 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Carbolines
• Indoles
• 6-methoxytryptoline

Topics

• Adult
• Carbolines (analysis, blood, cerebrospinal fluid)
• Female
• Gas Chromatography-Mass Spectrometry
• Humans
• Indoles (analysis)
• Male
• Schizophrenia (blood, cerebrospinal fluid, metabolism)