Abstract |
In anesthetized pigs, the influence on cardiovascular performance and on survival rate of IV administration of a large dose of endotoxin (0.5 mg/kg of body weight) was examined. This dose of endotoxin (LD100) resulted in a progressively evolving deterioration of cardiovascular functions and in the death of all animals within 210 minutes (mean +/- SEM: 107 +/- 13 minutes) after it was given. The IV injection of prednisolone sodium succinate, 10 mg/kg at 25 minutes before dosing the pigs with endotoxin resulted in a significant increase in survival time. This effect of the glycocorticoid can only partly be ascribed to an amelioration of the cardiovascular dysfunctions.
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Authors | E M Schrauwen, A M Houvenaghel |
Journal | American journal of veterinary research
(Am J Vet Res)
Vol. 45
Issue 8
Pg. 1650-3
(Aug 1984)
ISSN: 0002-9645 [Print] United States |
PMID | 6476579
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Prednisolone
- prednisolone hemisuccinate
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Topics |
- Animals
- Cardiovascular System
(drug effects)
- Female
- Prednisolone
(administration & dosage, analogs & derivatives, pharmacology, therapeutic use)
- Shock, Septic
(mortality, prevention & control, veterinary)
- Swine
- Swine Diseases
(mortality, prevention & control)
- Time Factors
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