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Endotoxin shock in the pig: beneficial effects of pretreatment with prednisolone sodium succinate.

Abstract
In anesthetized pigs, the influence on cardiovascular performance and on survival rate of IV administration of a large dose of endotoxin (0.5 mg/kg of body weight) was examined. This dose of endotoxin (LD100) resulted in a progressively evolving deterioration of cardiovascular functions and in the death of all animals within 210 minutes (mean +/- SEM: 107 +/- 13 minutes) after it was given. The IV injection of prednisolone sodium succinate, 10 mg/kg at 25 minutes before dosing the pigs with endotoxin resulted in a significant increase in survival time. This effect of the glycocorticoid can only partly be ascribed to an amelioration of the cardiovascular dysfunctions.
AuthorsE M Schrauwen, A M Houvenaghel
JournalAmerican journal of veterinary research (Am J Vet Res) Vol. 45 Issue 8 Pg. 1650-3 (Aug 1984) ISSN: 0002-9645 [Print] United States
PMID6476579 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Prednisolone
  • prednisolone hemisuccinate
Topics
  • Animals
  • Cardiovascular System (drug effects)
  • Female
  • Prednisolone (administration & dosage, analogs & derivatives, pharmacology, therapeutic use)
  • Shock, Septic (mortality, prevention & control, veterinary)
  • Swine
  • Swine Diseases (mortality, prevention & control)
  • Time Factors

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