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Chlorpropamide hepatotoxicity: report of a case and review of the literature.

Abstract
Chlorpropamide, a sulfonylurea compound used in the treatment of diabetes mellitus, type II, has been implicated as the cause of untoward reactions involving the hematopoietic, cutaneous, and gastrointestinal systems. The hepatotoxic reactions induced by this drug generally present as hepatocanalicular cholestatic reactions, in contrast to the hepatocellular reactions induced by the older sulfonylurea compounds. An unusual presentation of chlorpropamide toxicity, presenting as a mixed hepatocanalicular reaction, is reported, along with a review of the literature.
AuthorsH L Schneider, K D Hornbach, J L Kniaz, M E Efrusy
JournalThe American journal of gastroenterology (Am J Gastroenterol) Vol. 79 Issue 9 Pg. 721-4 (Sep 1984) ISSN: 0002-9270 [Print] United States
PMID6475904 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Chlorpropamide
Topics
  • Biopsy
  • Chemical and Drug Induced Liver Injury (diagnosis, etiology, pathology)
  • Chlorpropamide (adverse effects)
  • Female
  • Humans
  • Liver (pathology)
  • Middle Aged

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