Antineoplastic activity of ASTA Z 7557 (INN mafosfamide) in transplanted and autochthonous experimental rodent tumors.

Abstract

The antineoplastic activities of ASTA Z 7557 and cyclophosphamide (CPA) were compared in advanced transplanted AKR lymphoma by determining the optimal dose using single dose and twofold applications. Autochthonous DMBA-induced leukemias and MNU-induced mammary carcinomas were treated with fractionated doses over 3 and 5 weeks, respectively. In the respective optimal dosages ASTA Z 7557 exhibited an antitumor effect comparable to that of CPA in all three models. The results obtained by treatment of the autochthonous models indicate that Z 7557 seems to have advantages over CPA in the treatment of malignancies with impaired bone marrow function as for instance acute leukemias and in fractionated dose schedules.

• Authors: W J Zeller, M R Berger, R Matys, J Schuhmacher
• Journal: Investigational new drugs (Invest New Drugs) Vol. 2 Issue 2 Pg. 175-80 ( 1984) ISSN: 0167-6997 [Print] United States
• PMID: 6469512 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Asta Z 7557
• Cyclophosphamide

Topics

• Animals
• Cyclophosphamide (administration & dosage, analogs & derivatives, therapeutic use)
• Female
• Leukemia, Experimental (chemically induced, drug therapy)
• Lymphoma (drug therapy)
• Male
• Mammary Neoplasms, Experimental (chemically induced, drug therapy)
• Mice
• Mice, Inbred AKR
• Neoplasm Transplantation
• Rats
• Rats, Inbred Strains