Activity of Carbetimer in a human tumor cloning system.

Abstract

The antitumor activity of Carbetimer was tested against 171 patient's tumors in a human tumor cloning system. Sixty-seven tumor specimens had adequate growth to be considered evaluable. In 21 specimens survival of tumor colony forming units was less than or equal to 50% that in control plates. Antitumor effect was most impressive in carcinomas of the breast, ovary, and lung. This information will be useful in planning disease oriented Phase II trials.

• Authors: D L Kisner, P Mehta, G E Paget, D D Von Hoff
• Journal: Investigational new drugs (Invest New Drugs) Vol. 2 Issue 1 Pg. 55-8 ( 1984) ISSN: 0167-6997 [Print] United States
• PMID: 6469499 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Polymers
• carboxyimamidate

Topics

• Antineoplastic Agents (pharmacology)
• Colony-Forming Units Assay
• Humans
• Polymers (pharmacology)