[Comparative study on the efficacy of disopyramide and propafenone in the prevention of the recurrence of ventricular tachycardia].

Abstract

The purpose of our study was to assess the efficacy of Propafenon in comparison with Disopyramide in the long-term treatment of repetitive ventricular tachycardia. We studied 34 patients suffering from episodes of repetitive ventricular tachycardia of different etiology. Propafenon and Disopyramide was administered in doses of 300 mg and 200 mg three times a day respectively. The number of ventricular tachycardias has been evaluated during a period of 4 months of basal observation and during two periods of 4 months each of treatment respectively with Disopyramide and Propafenon. Moreover a dynamic electrocardiogram was recorded to assess the efficacy of Propafenon in suppressing ventricular ectopic beats in 17 patients. We conclude that Propafenon shows greater efficacy than Disopyramide in the treatment of repetitive ventricular tachycardias and a comparable efficacy in the control of ventricular ectopic beats. Moreover Propafenon shows also a minor incidence of side effects.

• Authors: M Palmieri, A Capucci, G Lombardi, F Naccarella, E Bomba, D Bracchetti
• Journal: Giornale italiano di cardiologia (G Ital Cardiol) Vol. 14 Issue 5 Pg. 357-9 (May 1984) ISSN: 0046-5968 [Print] Italy
• Vernacular Title: Studio comparativo sull'efficacia della disopiramide e del propafenone nella prevenzione delle recidive di tachicardia ventricolare.
• PMID: 6468817 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Anti-Arrhythmia Agents
• Propiophenones
• Propafenone
• Disopyramide

Topics

• Anti-Arrhythmia Agents (therapeutic use)
• Disopyramide (therapeutic use)
• Drug Evaluation
• Heart Ventricles
• Humans
• Propafenone
• Propiophenones (therapeutic use)
• Recurrence
• Tachycardia (drug therapy)