Chronic active hepatitis in mice induced by 3-hydroxy-4-pyrone.

Abstract

Chronic active hepatitis was selectively induced in mice by the feeding of a diet containing 3-hydroxy-4-pyrone (0.5% by weight) for periods of 6 weeks and longer. This model should be of particular value in elucidating the pathogenesis of drug-induced forms of chronic active hepatitis. Maltol (3-hydroxy-2-methyl-4-pyrone) did not produce any liver lesion.

• Authors: P S Bhathal, S L Ho, M P Hegarty, R L Harris
• Journal: Experientia (Experientia) Vol. 40 Issue 8 Pg. 894-6 (Aug 15 1984) ISSN: 0014-4754 [Print] Switzerland
• PMID: 6468611 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Chromones
• pyromeconic acid

Topics

• Animals
• Chemical and Drug Induced Liver Injury, Chronic
• Chromones (administration & dosage)
• Diet
• Disease Models, Animal
• Female
• Hepatitis, Chronic (pathology)
• Liver (pathology)
• Mice