Potentiation by SKF 525A of the pressor responses to catecholamines, oxytocin and carotid occlusion in rats.

Abstract

The effect of SKF 525A (20 mg/kg i.v.) on pressor responses of various origin was studied. SKF 525A abolished or markedly reduced the pressor responses to ganglionic stimulants (DMPP and McN-A-343), but potentiated those to noradrenaline (in normal and pithed animals), adrenaline, tyramine, oxytocin and carotid occlusion. After recovery of the pressor effect of McN-A-343 from the SKF 525A-induced suppression, the pressor effect of noradrenaline was still further enhanced. The abolition of the pressor responses to ganglionic stimulants is due to the ganglion and adrenal-medullary blocking action of SKF 525A. This action of SKF 525A is of secondary importance for its potentiating effect. It is tentatively suggested that for the SKF 525A-induced potentiation a partial depolarization of arterial smooth muscle membrane resulting from a prolonged release of subthreshold concentrations of catecholamines from tissue stores, may be of primary importance.

• Authors: M K Krstić
• Journal: Archives internationales de pharmacodynamie et de therapie (Arch Int Pharmacodyn Ther) Vol. 269 Issue 1 Pg. 52-62 (May 1984) ISSN: 0003-9780 [Print] Belgium
• PMID: 6466007 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Catecholamines
• Ganglionic Stimulants
• Oxytocin
• Dimethylphenylpiperazinium Iodide
• Proadifen
• Norepinephrine
• Tyramine
• Epinephrine

Topics

• Animals
• Blood Pressure (drug effects)
• Carotid Arteries (physiology)
• Catecholamines (pharmacology)
• Dimethylphenylpiperazinium Iodide (pharmacology)
• Drug Synergism
• Epinephrine (pharmacology)
• Female
• Ganglionic Stimulants (pharmacology)
• Male
• Norepinephrine (pharmacology)
• Oxytocin (pharmacology)
• Proadifen (pharmacology)
• Rats
• Rats, Inbred Strains
• Tyramine (pharmacology)