Comparative trial of oltipraz versus praziquantel in the treatment of urinary schistosomiasis in the Gabon.

Abstract

The efficacy of oltipraz as a schistosomicidal drug was investigated in Gabonese children suffering from urinary schistosomiasis in the dosages of 1 X 25 mg/kg body weight, 1 X 35 mg/kg body weight, and 2 X 20 mg/kg body weight and compared to praziquantel, 2 X 30 mg/kg body weight. The study was undertaken in 165 patients, and follow-up investigations were carried out 6 weeks and 12 weeks after treatment. Oltipraz showed less efficacy compared to praziquantel when dosages of 1 X 25 and 1 X 35 mg/kg body weight were given. However, oltipraz 2 X 20 mg/kg body weight was equivalent to praziquantel 2 X 30 mg/kg body weight. Parasitological cure was obtained in 79% of patients treated by oltipraz and 81% of patients treated by praziquantel. Side effects were insignificant in both treatment groups. Thus, the same parasitological cure could be achieved by oltipraz as well as by praziquantel, but with a lower dosage of oltipraz.

• Authors: G D Burchard, P Kern, R Baltes, M Dietrich
• Journal: Tropenmedizin und Parasitologie (Tropenmed Parasitol) Vol. 35 Issue 2 Pg. 91-4 (Jun 1984) ISSN: 0303-4208 [Print] Germany
• PMID: 6464191 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Isoquinolines
• Pyrazines
• Schistosomicides
• Thiones
• Thiophenes
• Praziquantel
• oltipraz

Topics

• Adolescent
• Child
• Female
• Gabon
• Humans
• Isoquinolines (therapeutic use)
• Male
• Parasite Egg Count
• Praziquantel (administration & dosage, therapeutic use)
• Pyrazines (administration & dosage, therapeutic use)
• Schistosoma
• Schistosoma haematobium
• Schistosomiasis (drug therapy)
• Schistosomicides (administration & dosage, therapeutic use)
• Species Specificity
• Thiones
• Thiophenes
• Urine (parasitology)
• Urologic Diseases (drug therapy)