Calcium antagonist PY 108-068: demonstration of its efficacy in various types of experimental brain ischemia.

Abstract

The protective properties of PY 108-068 against ischemic disturbances in the brain were investigated in vitro and in vivo. The calcium antagonistic effects were demonstrated on isolated, calcium-loaded arterial rings of feline cerebral arteries. Determination of brain tissue oxygenation with pO2 microelectrodes showed that PY 108-068 improved oxygen supply in the cortex of cats subjected to epicerebral arterial occlusion. In a model of cerebral vasospasm induced by autologous blood superfusion, PY 108-068 reversed the spastic state of cortical microvessels. In a chronic stroke model (microsphere embolization in rats) PY 108-068 led to a significant reduction in mortality and in the severity of neurological symptoms, whereby the peroral efficacy of the drug could be demonstrated. The efficacy of PY 108-068 in a variety of ischemic insults makes this drug a promising aid in the treatment of cerebrovascular accidents.

• Authors: N Wiernsperger, P Gygax, A Hofmann
• Journal: Stroke (Stroke) 1984 Jul-Aug Vol. 15 Issue 4 Pg. 679-85 ISSN: 0039-2499 [Print] United States
• PMID: 6464060 (Publication Type: Journal Article)

Chemical References

• Calcium Channel Blockers
• Nifedipine
• darodipine
• Oxygen

Topics

• Animals
• Body Water (analysis)
• Brain Ischemia (drug therapy)
• Calcium Channel Blockers (therapeutic use)
• Cats
• Cerebral Cortex (analysis)
• In Vitro Techniques
• Intracranial Embolism and Thrombosis (drug therapy)
• Ischemic Attack, Transient (drug therapy)
• Nifedipine (analogs & derivatives, therapeutic use)
• Oxygen (analysis)
• Partial Pressure
• Rats
• Rats, Inbred F344