T-2 toxin effect on bacterial infection and leukocyte functions.

The effects of T-2 toxin on bacterial infection and leukocyte function and structure were examined in vivo and in vitro. Rats were innoculated with staphylococci after pretreatment with or without T-2 toxin. The T-2 pretreated rats failed to mount a cellular response to the bacteria. Blood and bone marrow cells were markedly suppressed by the T-2 toxin, the myeloid series being the most affected. In vitro studies with human leukocytes showed that small, nonkilling doses of T-2 toxin inhibited chemotaxis, chemiluminescence stimulated by bacteria, and phagocytosis of bacteria. It was concluded that this inhibition may contribute towards sepsis and rapid onset of death in T-2 toxin poisoning.
AuthorsR Yarom, Y Sherman, R More, I Ginsburg, R Borinski, B Yagen
JournalToxicology and applied pharmacology (Toxicol Appl Pharmacol) Vol. 75 Issue 1 Pg. 60-8 (Aug 1984) ISSN: 0041-008X [Print] UNITED STATES
PMID6464023 (Publication Type: Journal Article)
Chemical References
  • Sesquiterpenes
  • T-2 Toxin
  • Animals
  • Blood (drug effects)
  • Bone Marrow (drug effects)
  • Chemotaxis (drug effects)
  • Humans
  • Leukocyte Count
  • Leukocytes (drug effects, pathology)
  • Male
  • Phagocytosis (drug effects)
  • Rats
  • Sesquiterpenes (pharmacology)
  • Staphylococcal Infections
  • T-2 Toxin (pharmacology)

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