Oxiconazole in the treatment of vaginal candidiasis: single dose versus 3-day treatment with econazole.

Abstract

Fifty-one women with vaginal candidiasis were included in an open randomized study to compare the efficacy and local tolerance of a single-dose treatment with 600 mg oxiconazole (one vaginal tablet) with that of a 3-day treatment with econazole (one 150 mg ovule daily). Twenty-five patients were treated with oxiconazole and the remaining 26 received econazole. Patients were followed-up 1 week and 4 to 5 weeks after the initial examination and details were recorded of the results of yeast culture, the clinical signs and symptoms present and any signs of intolerance. A cure rate of 92% was achieved in both treatment groups and only 1 patient (econazole group) of the 4 treatment failures (2 in each group) did not respond to a subsequent second course with the same treatment schedule. Vaginal burning was the only reported local side-effect in 5 patients of the oxiconazole group and in 6 of the econazole group.

• Authors: D C Gouveia, C Jones da Silva
• Journal: Pharmatherapeutica (Pharmatherapeutica) Vol. 3 Issue 10 Pg. 682-5 ( 1984) ISSN: 0308-051X [Print] England
• PMID: 6463068 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Antifungal Agents
• Imidazoles
• Econazole
• oxiconazole

Topics

• Adult
• Antifungal Agents (administration & dosage, therapeutic use)
• Candidiasis, Vulvovaginal (drug therapy)
• Drug Administration Schedule
• Econazole (administration & dosage, therapeutic use)
• Female
• Humans
• Imidazoles (administration & dosage, therapeutic use)
• Middle Aged
• Random Allocation