The effect of nonspecific immune stimulation with Corynebacterium parvum and polidin on the Ehrlich ascites tumor growth.

Abstract

Investigations were performed: a) to compare the effect of two nonspecific immunostimulants, Polidin and Corynebacterium parvum, on the development of Ehrlich ascites carcinoma in mice; b) to determine whether the effects are dependent on the tumor cell dose inoculated into the animals. C. parvum and Polidin administered prior to Ehrlich ascites tumor inoculation have a protective effect evidenced by a delay in tumor development, a retardation in tumor growth and a prolonged survival of the tumor host. The effect of immunostimulants was highly dependent on the tumor cell dose inoculated into mice and was more marked with C. parvum.

• Authors: C Todoruţiu, R Rişcă, D Daicoviciu, R Mulea
• Journal: Morphologie et embryologie (Morphol Embryol (Bucur)) 1982 Jan-Mar Vol. 28 Issue 1 Pg. 77-83 ISSN: 0377-5038 [Print] Romania
• PMID: 6461826 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Adjuvants, Immunologic
• Benzilates
• poldine

Topics

• Adjuvants, Immunologic (therapeutic use)
• Animals
• Benzilates (therapeutic use)
• Carcinoma, Ehrlich Tumor (prevention & control)
• Female
• Immunization
• Mice
• Neoplasm Transplantation
• Propionibacterium acnes (immunology)