MAO activity, csf amine metabolites, and drug-free improvement in schizophrenia.

Platelet monoamine oxidase (MAO) activity and amine metabolites in cerebrospinal fluid were compared in 22 schizophrenic patients, 8 of whom improved during a 30-day drug-free period. CSF 5-hydroxyindoleacetic acid and homovanillic acid did not distinguish between drug-free improvers and nonimprovers. However, drug-free improvers had lower platelet MAO activities than did normal controls. The authors suggest that looking at clinical variables in patients with low MAO activity might provide a means of biologically subtyping schizophrenic patients.
AuthorsD P Van Kammen, S R Marder, D L Murphy, W E Bunney Jr
JournalThe American journal of psychiatry (Am J Psychiatry) Vol. 135 Issue 5 Pg. 567-9 (May 1978) ISSN: 0002-953X [Print] UNITED STATES
PMID645949 (Publication Type: Journal Article)
Chemical References
  • Phenylacetates
  • Tranquilizing Agents
  • Hydroxyindoleacetic Acid
  • Monoamine Oxidase
  • Homovanillic Acid
  • Adolescent
  • Adult
  • Blood Platelets (enzymology)
  • Female
  • Homovanillic Acid (cerebrospinal fluid)
  • Humans
  • Hydroxyindoleacetic Acid (cerebrospinal fluid)
  • Male
  • Middle Aged
  • Monoamine Oxidase (metabolism)
  • Phenylacetates (cerebrospinal fluid)
  • Remission, Spontaneous
  • Schizophrenia (blood, cerebrospinal fluid, metabolism)
  • Tranquilizing Agents (therapeutic use)

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