Abstract |
The epiphyseal plates of newborn normal (Cd/?), dwarf (Dw/Dw) and achondroplastic (ac/ac) rabbits were grown in organ culture for 48 hours. The 3H-thymidine labeling index of proliferating zone chondrocytes from both mutants was below that of normals. The generation time of Dw/Dw animals was longer than that of normals (greater than 24 vs. 17 hours respectively). Inasmuch as the medium was supplemented with 10% fetal calf serum, which presumably contains somatomedin, these data suggest that the Dw/Dw mutant cannot be considered simply a model for pituitary dwarfism. Pituitary fibroblast growth factor (FGF), 50ng/ml, decreased the labeling index of chondrocytes from both Dw/Dw and ac/ac animals. Thus neither a lack of FGF nor an end-organ non-responsiveness to this factor seems to play a role in the pathogenesis of either growth disturbance.
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Authors | R J Webber, R R Fox, L Sokoloff |
Journal | Growth
(Growth)
Vol. 45
Issue 3
Pg. 269-78
( 1981)
ISSN: 0017-4793 [Print] United States |
PMID | 6458543
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Growth Substances
- Peptides
- Fibroblast Growth Factors
|
Topics |
- Achondroplasia
(pathology)
- Animals
- Cartilage
(pathology)
- Cell Division
- Cells, Cultured
- Dwarfism
(pathology)
- Epiphyses
(pathology)
- Fibroblast Growth Factors
- Growth Substances
(pharmacology)
- Mutation
- Organ Culture Techniques
- Peptides
(pharmacology)
- Rabbits
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