Evaluation of therapeutic efficacy of ureidopenicillins in comparison to sisomicin and cephalotin in experimental infections of rabbits.

Abstract

The therapeutic efficacy of azlocillin, mezlocillin, cephalotin, and sisomicin was evaluated by experimental infection in rabbits. After one hour following infection with Escherichia coli, Klebsiella pneumoniae or Pseudomonas aeruginosa, antibiotics were applied intramuscularly. Colony-forming units were counted before the infection and every day thereafter. Leukocytosis was determined before infection and 3 and 7 days after initiation of therapy. Therapy with antibiotics was continued for seven days, rabbits sacrificed and CFU/g tissue determined. It was shown that in experimental infection caused by E. coli or K. pneumoniae in rabbits, sisomicin was most effective, followed by mezlocillin, azlocillin, and cephalotin. Efficacy of therapy against P. aeruginosa was as follows: sisomicin, azlocillin, mezlocillin.

• Authors: D Dzierzanowska, E Klosinska, W Roszkowski, J Patzer, J Jeljaszewicz
• Journal: Zentralblatt fur Bakteriologie, Mikrobiologie und Hygiene. 1. Abt. Originale A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie = International journal of microbiology and hygiene. A, Medical microbiology, infectious... (Zentralbl Bakteriol Mikrobiol Hyg A Med Mikrobiol Infekt Parasitol) Vol. 250 Issue 3 Pg. 312-21 (Sep 1981) ISSN: 0174-3031 [Print] Germany
• PMID: 6458186 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Penicillins
• Azlocillin
• Mezlocillin
• Cephalothin
• Sisomicin

Topics

• Animals
• Azlocillin
• Cephalothin (therapeutic use)
• Drug Evaluation, Preclinical
• Escherichia coli Infections (drug therapy)
• Klebsiella Infections (drug therapy)
• Klebsiella pneumoniae
• Mezlocillin
• Penicillins (therapeutic use)
• Pseudomonas Infections (drug therapy)
• Rabbits
• Sisomicin (therapeutic use)