Scleromyxedema myopathy. Histochemical and electron microscopic observations.

Abstract	A biopsy-proven case of scleromyxedema (papular mucinosis) with IgG lambda light chain paraproteinemia, eosinophilia and severe proximal myopathy is presented. Muscle biopsy revealed an atypical necrotizing vacuolar myopathy. Histochemical studies of cryostat sections revealed fiber necrosis, severe type II fiber atrophy, and fiber vacuolization with NADH tetrazolium reductase hyperactivity. Electron microscopy showed myocytolysis, reduplication of the basement membrane, and unit membrane-lined vacuoles negative for acid mucopolysaccharide.
Authors	M A Verity, J Toop, L P McAdam, C M Pearson
Journal	American journal of clinical pathology (Am J Clin Pathol) Vol. 69 Issue 4 Pg. 446-51 (Apr 1978) ISSN: 0002-9173 [Print] England
PMID	645644 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References	NADH Tetrazolium Reductase
Topics	Biopsy Eosinophilia (complications) Female Histocytochemistry Humans Middle Aged Muscles (enzymology, ultrastructure) Muscular Diseases (enzymology, pathology) Myxedema (enzymology, pathology) NADH Tetrazolium Reductase (metabolism) Paraproteinemias (complications)

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