Antitumor effect of 3-[3-(2-chloroethyl)-3-nitrosoureido]-3-deoxy-D-glucopyranose on murine tumors.

Abstract

The antitumor activity of a new derivative of nitrosourea, 3-[3-(2-chloroethyl)-3-nitrosoureido]-3-deoxy-D-glucopyranose (CNUG), against murine tumors was studied. CNUG showed remarkable antitumor activity against leukemias L1210 and P388, Lewis lung carcinoma, and sarcoma-180 (solid form). In particular, the majority of mice with leukemia or sarcoma-180 tumor were cured when they were given a single injection of CNUG on day 1 after tumor inoculation, and this treatment was more effective than daily treatment. CNUG was also active against sarcoma-180 grown in the brain, lung, liver or under the capsule of the kidney, and even against autochthonous lung tumor induced by 1-ethyl-1-nitrosourea. The number of peripheral leucocytes was depressed by the treatment with CNUG but this depression was less than that with 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea.

• Authors: K Komiyama, K Edanami, T Kuroda, I Umezawa
• Journal: Gan (Gan) Vol. 72 Issue 1 Pg. 53-9 (Feb 1981) ISSN: 0016-450X [Print] Japan
• PMID: 6456168 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Semustine
• chlorozotocin
• Streptozocin

Topics

• Animals
• Antineoplastic Agents (administration & dosage, therapeutic use)
• Chemical Phenomena
• Chemistry
• Leukemia, Experimental (drug therapy)
• Leukocyte Count
• Male
• Mice
• Mice, Inbred Strains
• Neoplasms, Experimental (drug therapy)
• Semustine (therapeutic use)
• Streptozocin (administration & dosage, analogs & derivatives, therapeutic use)