Abstract |
The clinical efficacy and tolerance of a new retinoic acid derivative, Ro 11-1430, in the treatment of acne vulgaris have been compared with those of tretinoin in a double-blind trial with 60 patients during 8 weeks. The efficacy of both drugs was good. Tretinoin showed a tendency to give better effect but this was not statistically significant. However, tolerance of the new derivative was better. 48 of the patients were treated with Ro 11-1430 for another 3 months with good effect and tolerance. In a long-term study, 32 patients with previous irritation of tretinoin have been treated with Ro 11-1430 between 1.5 and 17 months with good tolerance.
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Authors | K Nordin, T Fredriksson, C Rylander |
Journal | Dermatologica
(Dermatologica)
Vol. 162
Issue 2
Pg. 104-11
( 1981)
ISSN: 0011-9075 [Print] Switzerland |
PMID | 6454596
(Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)
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Chemical References |
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Topics |
- Acne Vulgaris
(drug therapy)
- Administration, Topical
- Adolescent
- Adult
- Chemical Phenomena
- Chemistry
- Child
- Clinical Trials as Topic
- Double-Blind Method
- Drug Tolerance
- Female
- Humans
- Male
- Tretinoin
(administration & dosage, analogs & derivatives, therapeutic use)
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