This study was designed to investigate effects of
immunopotentiator on
cervical cancer. We administered
schizophyllan (SPG) as
immunopotentiator to patients of
cervical cancer therapy with irradiation, and examined successively immunological parameters such as blastformation of lymphocytes, skin reaction of
PPD, lymphocyte counts, concentration of serum
immunoglobulins, and other clinical inspections. Moreover we examined ability of
interferon induction of SPG. We also calculated and compared 3 year relative survival rate of the cases administered SPG and historical controls
therapy with only irradiation. In patients administered SPG the results revealed: 1) an enhancement of stimulation index of lymphocytes blastformation with PHA, 2) an enlargement of skin reaction to
PPD, 3) no effects to number of lymphocytes, serum
immunoglobulins, liver function and renal function, 4) an
interferon activity on patients' sera of
cervical cancer after administration of SPG, and 5) patients administrated SPG had significantly high relative survival rate in comparison with the historical control of
cervical cancer cases treated solely by irradiation.