HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Increased fibrinopeptide A formation and thromboxane A2 production in patients with ischemic heart disease: relationships to coronary pathoanatomy, risk factors, and clinical manifestations.

Abstract
In 98 patients with ischemic heart disease (IHD), independent of their clinical status (previous myocardial infarction, spontaneous angina or effort angina), a hypercoagulable state (indicated by significant elevation of fibrinopeptide A plasma level) and an increased platelet biologic activity were observed. Moreover, plasma fibrinopeptide A concentration and platelet aggregation were remarkably higher in patients with frequently occurring spontaneous clinical manifestations (active disease) than in IHD patients with relatively quiescent symptoms. Abnormalities of blood clotting and platelet changes were not significantly altered by the presence of severity of coronary angiographic fixed obstruction in IHD. Multiple regression analysis indicated that hypercoagulability and increased platelet biologic activity were not a consequence of differences in risk factor patterns in IHD patients compared to control subjects.
AuthorsG G Neri Serneri, G F Gensini, R Abbate, C Mugnaini, S Favilla, C Brunelli, S Chierchia, O Parodi
JournalAmerican heart journal (Am Heart J) Vol. 101 Issue 2 Pg. 185-94 (Feb 1981) ISSN: 0002-8703 [Print] UNITED STATES
PMID6451162 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Thromboxanes
  • beta-Thromboglobulin
  • Fibrinopeptide A
  • Thromboxane A2
  • Fibrinogen
Topics
  • Blood Coagulation
  • Blood Platelets (metabolism)
  • Coronary Disease (blood, pathology)
  • Female
  • Fibrinogen (biosynthesis)
  • Fibrinopeptide A (biosynthesis)
  • Hemostasis
  • Humans
  • Male
  • Middle Aged
  • Platelet Aggregation
  • Risk
  • Thromboxane A2 (blood)
  • Thromboxanes (blood)
  • beta-Thromboglobulin (analysis)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: