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The pharmacokinetics and tumor and neural tissue penetrating properties of SR-2508 and SR-2555 in the dog--hydrophilic radiosensitizers potentially less toxic than misonidazole.

AuthorsR A White, P Workman, J M Brown
JournalRadiation research (Radiat Res) Vol. 84 Issue 3 Pg. 542-61 (Dec 1980) ISSN: 0033-7587 [Print] UNITED STATES
PMID6450431 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Nitroimidazoles
  • Radiation-Sensitizing Agents
  • Etanidazole
  • SR 2555
  • Misonidazole
Topics
  • Administration, Oral
  • Animals
  • Biological Availability
  • Dog Diseases (metabolism)
  • Dogs
  • Drug Evaluation, Preclinical
  • Etanidazole
  • Female
  • Injections, Intravenous
  • Kinetics
  • Male
  • Misonidazole (administration & dosage, metabolism)
  • Neoplasms (metabolism, veterinary)
  • Nervous System (metabolism)
  • Nitroimidazoles (administration & dosage, metabolism)
  • Radiation-Sensitizing Agents
  • Structure-Activity Relationship

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