[Treatment of severe febrile neutropenia (author's transl)].

Abstract

Random allocation of 22 patients with benign and malignant diseases with neutrophil counts of up to 1 X 10(9)/l blood and probably infection-caused fever of more than 38 degrees C to intravenous treatment with one of the following antibiotic combinations was performed: carbenicillin (6 g/m(2) . 6 h) plus sisomicin (45 g/m2 . 6 h) or mezlocillin (3 g/m2 . 6 h) plus sisomicin (45 g/m2 . 6 h). Both combinations were tolerated equally well. Patients became afebrile in 16 out of 23 treatment periods. Seven out of 11 patients responded to carbenicillin - sisomicin, and 9 out of 12 to mezlocillin - sisomicin. Mezlocillin thus leads to equal success of treatment in febrile neutropenia as the double dose of carbenicillin when both antibiotics are combined with the same aminoglycoside.

• Authors: G Meuret, A Roux, M E Heim, M Westerhausen
• Journal: Deutsche medizinische Wochenschrift (1946) (Dtsch Med Wochenschr) Vol. 105 Issue 51 Pg. 1776-9 (Dec 19 1980) ISSN: 0012-0472 [Print] Germany
• Vernacular Title: Zur Behandlung der schweren febrilen Neutropenie.
• PMID: 6449360 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Gentamicins
• Penicillins
• Carbenicillin
• Mezlocillin
• Sisomicin

Topics

• Agranulocytosis (drug therapy)
• Carbenicillin (administration & dosage, therapeutic use)
• Drug Evaluation
• Drug Therapy, Combination
• Fever (drug therapy)
• Gentamicins (therapeutic use)
• Humans
• Mezlocillin
• Neutropenia (drug therapy, etiology)
• Penicillins (administration & dosage, therapeutic use)
• Random Allocation
• Sisomicin (administration & dosage, therapeutic use)