Selective IgA deficiency: clinical and immunological evaluation of 50 pediatric patients.

Abstract

Fifty children with IgA deficiency were folllowed for 1 to 4 years from 1975 to 1978. Thirty-five had complete deficiency of serum IgA (less than 2.5 IU/ml) and 15 partial deficiency (serum IgA below the 10th centile for age). Patients with another associated immunodeficiency, such as ataxia-telangiectasia, were not included. Most children with complete deficiency of IgA had recurrent respiratory and/or gastrointestinal infections, about half with onset in the first year of life, while partial deficiency of IgA has probably little if any importance for anti-infectious immunity but is important in the pathogenesis of atopy. Atopic diseases were frequent in both groups. Chromosomal abnormalities were found in 2 patients: trisomy 21 in one and in the other a ring chromosome 18. No important defects in cellular immunity were detected but some isolated, borderline abnormalities were often present.

• Authors: G R Burgio, M Duse, V Monafo, A Ascione, L Nespoli
• Journal: European journal of pediatrics (Eur J Pediatr) Vol. 133 Issue 2 Pg. 101-6 (Mar 1980) ISSN: 0340-6199 [Print] Germany
• PMID: 6444875 (Publication Type: Journal Article)

Chemical References

• Immunoglobulin A

Topics

• Child
• Child, Preschool
• Chromosome Aberrations (immunology)
• Chromosome Disorders
• Chromosomes, Human, 16-18
• Down Syndrome (immunology)
• Dysgammaglobulinemia (immunology)
• Female
• Gastroenteritis (immunology)
• Humans
• IgA Deficiency
• Immunity, Cellular
• Immunoglobulin A (analysis)
• Infant
• Male
• Recurrence
• Respiratory Tract Infections (immunology)