Abstract |
In ACI/N rats pretreated with cyclophosphamide (CY) growth of the bladder cancer, BC-47, and adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP) activities in lymphocytes were investigated to clarify the possible antitumor effect via the immune system of the chemotherapeutic agent. A single dose of 50 mg/kg of CY with the tumor implantation 3 days later gave rise to tumor regression following temporary progression around day 15 and significant increase of peripheral lymphocytes with higher PNP activity on days 7 to 10 of the tumor implantation. In the thymus such lymphocytes increased 3 days earlier. The antitumor effect was not demonstrated in athymic nude mice. In the light of the results and elimination of suppressor T precursors by CY, it was postulated that T lymphocytes with higher PNP activity act as effector cells in the antitumor immunity whereas suppressor T precursors belong to the cell population with lower PNP activity.
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Authors | T Iwaguchi, M Nakamura, H Kitagawa |
Journal | The Japanese journal of experimental medicine
(Jpn J Exp Med)
Vol. 54
Issue 5
Pg. 201-6
(Oct 1984)
ISSN: 0021-5031 [Print] Japan |
PMID | 6442929
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cyclophosphamide
- Pentosyltransferases
- Purine-Nucleoside Phosphorylase
- Nucleoside Deaminases
- Adenosine Deaminase
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Topics |
- Adenosine Deaminase
(blood)
- Animals
- Cyclophosphamide
(therapeutic use)
- Kinetics
- Leukocyte Count
- Lymphocytes
(enzymology, immunology)
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Neoplasm Transplantation
- Nucleoside Deaminases
(blood)
- Pentosyltransferases
(blood)
- Purine-Nucleoside Phosphorylase
(blood)
- Rats
- Rats, Inbred ACI
- T-Lymphocytes
(immunology)
- Urinary Bladder Neoplasms
(drug therapy, immunology)
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