[Effect of nootropic agents on the lowering of the spasm threshold after a single ethanol application].

Abstract

We used the effect of ethanol on the convulsion threshold as model of injuriousness to analyse the CNS protective efficacy of nootropics. The CD50 of picrotoxine in mice was significantly diminished in comparision with the controls between 5 and 6 hours after 66 mmol/kg ethanol administered intraperitoneally and between 7 and 8 h after 92.4 mmol/kg. In this moment the administered ethanol was already eliminated; the effect is explained as a reversible consequence of the previous ethanol exposition. The influence of nootropics was examined. Piracetam (0.7 mmol/kg i.p.) as well as methylglucaminorotate (MGO) (0.68 mmol/kg-1 i.p.) suppressed the ethanol effect on the convulsibility, pyritinol (0.82 mmol/kg) was ineffective, and meclophenoxate (1.02 mmol/kg) by itself decreased the convulsions threshold.

• Authors: A Dienel, K Andreas, J Schmidt
• Journal: Biomedica biochimica acta (Biomed Biochim Acta) Vol. 43 Issue 10 Pg. 1179-84 ( 1984) ISSN: 0232-766X [Print] Germany
• Vernacular Title: Einfluss von Nootropika auf die Ernierdrigung der Krampfschwelle nach einmaliger Athanolapplikation.
• PMID: 6441574 (Publication Type: English Abstract, Journal Article)

Chemical References

• Picrotoxin
• Ethanol
• methylglucamine orotate
• Orotic Acid
• Meglumine
• Pyrithioxin
• Meclofenoxate
• Piracetam

Topics

• Animals
• Brain (drug effects)
• Ethanol (toxicity)
• Male
• Meclofenoxate (pharmacology)
• Meglumine (analogs & derivatives, pharmacology)
• Mice
• Orotic Acid (analogs & derivatives, pharmacology)
• Picrotoxin (pharmacology)
• Piracetam (pharmacology)
• Pyrithioxin (pharmacology)
• Seizures (chemically induced)
• Spasm (chemically induced)
• Time Factors