[Effect of an antiglucocorticoid steroid on the arterial hypertension induced by glucocorticoids in the rat].

Abstract

Hypertension was induced in male rats by administration of a glucocorticoid agonist, RU 26988. Systolic blood pressure (SBP) increased by 35 mmHg. Administration of an antimineralocorticoid derivative, RU 28318, did not modify hypertension. In contrast administration of a steroid derivative with antiglucocorticoid properties, RU 38486, prevented glucocorticoid-induced hypertension in a large part. SBP augmented only by 10 mmHg. The glucocorticoid increased total and active, ouabain-sensitive, 22Na efflux, as measured from caudal arteries, whereas concomitant administration of the antiglucocorticoid derivative prevented these changes. It is suggested that glucocorticoid-induced hypertension may be related to vascular Na pump activation and to the subsequent ionic changes. These changes, as well as hypertension, are antagonized by steroid derivatives with antiglucocorticoid properties.

• Authors: J P Grünfeld, L Eloy, A M Moura, D Ganeval, B Ramos-Frendo, M Worcel
• Journal: Archives des maladies du coeur et des vaisseaux (Arch Mal Coeur Vaiss) Vol. 77 Issue 11 Pg. 1158-61 (Oct 1984) ISSN: 0003-9683 [Print] France
• Vernacular Title: Effet d'un stéroïde antiglucocorticoïde sur l'hypertension artérielle induite par les glucocorticoïdes chez le rat.
• PMID: 6441535 (Publication Type: English Abstract, Journal Article)

Chemical References

• Androstanols
• Estrenes
• Glucocorticoids
• Mineralocorticoids
• Spironolactone
• Mifepristone
• RU 26988
• RU 28318
• Sodium

Topics

• Androstanols (antagonists & inhibitors, toxicity)
• Animals
• Blood Pressure (drug effects)
• Estrenes (pharmacology)
• Glucocorticoids (antagonists & inhibitors, toxicity)
• Hypertension (chemically induced)
• Male
• Mifepristone
• Mineralocorticoids (antagonists & inhibitors)
• Rats
• Rats, Inbred Strains
• Sodium (metabolism)
• Spironolactone (analogs & derivatives, pharmacology)