Protective effect of FR35447 on experimental cerebral infarction.

Abstract

The protective effect of 2-(5-chloro-2-phenoxyanilino)-2-imidazoline [FR35447] on cerebral infarction was examined in animal models. FR35447 in p.o. doses of 1 mg/kg or more caused a marked reduction of arachidonate-induced cerebral infarction in rats. Since FR35447 (10(-6) M) inhibited platelet aggregation induced by adrenaline plus the divalent cation ionophore A23187, as did yohimbine (10(-6) M), the protective effect of FR35447 is presumed to be due to its blocking activity on the alpha 2 adrenoceptors of platelets. However, additional mechanisms appear to participate in the protective effect of FR35447 on cerebral infarction. A ten-day treatment with FR35447 in p.o. doses of 1 to 10 mg/kg/day decreased serum lipid peroxide levels in vitamin E deficient rats, suggesting that FR35447 may have free radical scavenging activity. Moreover, FR35447 (greater than or equal to 10(-5) M) increased red cell deformability. These effects of FR35447 suggest that it may be useful in preventing or treating cerebral infarction.

• Authors: T Kamitani, K Katsuta, S Sakai, Y Sakata, Y Motoyama, H Horiai, T Ono, H Kikuchi, S Kumada
• Journal: Archives internationales de pharmacodynamie et de therapie (Arch Int Pharmacodyn Ther) Vol. 272 Issue 2 Pg. 264-76 (Dec 1984) ISSN: 0003-9780 [Print] Belgium
• PMID: 6441533 (Publication Type: Journal Article)

Chemical References

• Arachidonic Acids
• Cardiovascular Agents
• Imidazoles
• Lipid Peroxides
• Arachidonic Acid
• Yohimbine
• Calcimycin
• 2-(5-chloro-2-phenoxyanilino)-2-imidazoline
• Epoprostenol
• Prazosin
• Epinephrine

Topics

• Animals
• Arachidonic Acid
• Arachidonic Acids (toxicity)
• Calcimycin (pharmacology)
• Cardiovascular Agents (therapeutic use)
• Cerebral Infarction (blood, chemically induced, prevention & control)
• Epinephrine (pharmacology)
• Epoprostenol (pharmacology)
• Erythrocyte Deformability (drug effects)
• Imidazoles (therapeutic use)
• Lipid Peroxides (blood)
• Male
• Platelet Aggregation (drug effects)
• Prazosin (pharmacology)
• Rats
• Rats, Inbred Strains
• Vitamin E Deficiency (blood)
• Yohimbine (pharmacology)