Comparative incidence of oral ochratoxicosis and aflatoxicosis on the activity of drug-metabolizing enzymes in rat liver.

Abstract

Mycotoxicosis has been produced in the rat by daily oral administrations of ochratoxin A (1.5 mg/kg/day) or aflatoxin B1 (1 mg/kg/day). Hepatic microsomal cytochrome P-450 and b5 contents and many phase I and II biotransformation systems have been measured in the course of ochratoxicosis (4 to 15 dosings) and aflatoxicosis (1 to 8 dosings). In case of ochratoxicosis, decreases in cytochrome P-450 level, aminopyrine demethylase and aniline hydroxylase activities were observed in rats receiving 15 administrations of the toxin. Aflatoxicosis induced more severe decreases in cytochrome P-450, aminopyrine demethylase and ethoxycoumarin deethylase following 8 daily gavages. In the two studies, there was no significant change in activities of liver phase II biotransformation enzymes.

• Authors: P Galtier, G Larrieu, J Le Bars
• Journal: Toxicology letters (Toxicol Lett) Vol. 23 Issue 3 Pg. 341-7 (Dec 1984) ISSN: 0378-4274 [Print] Netherlands
• PMID: 6441316 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Aflatoxins
• Ochratoxins
• ochratoxin A
• Cytochrome P-450 Enzyme System
• Aflatoxin B1
• Oxygenases
• 7-Alkoxycoumarin O-Dealkylase
• Aniline Hydroxylase
• Aminopyrine N-Demethylase

Topics

• 7-Alkoxycoumarin O-Dealkylase
• Aflatoxin B1
• Aflatoxins (poisoning)
• Aminopyrine N-Demethylase (metabolism)
• Aniline Hydroxylase (metabolism)
• Animals
• Biotransformation (drug effects)
• Cytochrome P-450 Enzyme System (metabolism)
• Male
• Microsomes, Liver (drug effects, enzymology)
• Ochratoxins (poisoning)
• Oxygenases (metabolism)
• Rats
• Rats, Inbred Strains